GHK Copper
[CAS# 89030-95-5]

Identification

• Classification: Organic raw materials >> Organometallic compound >> Organic copper
• Name: GHK Copper
• Synonyms: [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper
• Molecular Formula: C₁₄H₂₂CuN₆O₄
• Molecular Weight: 401.91
• CAS Registry Number: 89030-95-5
• SMILES: C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)[O-])NC(=O)CN.[Cu+2]

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P280-P301+P312-P302+P352-P305+P351+P338

Discovory and Applicatios

GHK Copper, or Copper Glycyl-L-Histidyl-L-Lysine, is a peptide complex formed by the combination of a copper ion with the tripeptide GHK. This compound has garnered significant interest due to its unique biological properties and applications in various fields.

The discovery of GHK Copper dates back to the early 1970s when it was identified as a naturally occurring peptide in human plasma. Researchers found that this peptide complex could bind copper ions, which are essential for numerous biological processes. The initial interest in GHK Copper stemmed from its role in wound healing and tissue repair, leading to extensive research into its mechanisms of action.

In medical and cosmetic applications, GHK Copper is recognized for its remarkable regenerative properties. The compound has been shown to promote collagen and elastin synthesis, which are crucial for maintaining skin elasticity and reducing the appearance of aging. These properties make GHK Copper a popular ingredient in anti-aging skincare products and treatments. Clinical studies have demonstrated its effectiveness in improving skin texture, reducing fine lines, and accelerating the healing of wounds.

GHK Copper also plays a role in promoting cellular repair and reducing inflammation. Its ability to influence gene expression related to repair processes has made it a valuable tool in regenerative medicine. Research has explored its potential in treating chronic wounds, burns, and other tissue injuries by enhancing the body's natural healing responses.

In addition to its applications in skincare and regenerative medicine, GHK Copper has been investigated for its potential benefits in neuroprotection and cognitive health. Preliminary studies suggest that the peptide may have a role in protecting neuronal cells and improving cognitive function, although further research is needed to fully understand its impact in these areas.

Overall, GHK Copper represents a significant advancement in the fields of dermatology, regenerative medicine, and potentially neuroprotection. Its discovery and subsequent applications underscore its importance in improving health outcomes and advancing scientific understanding of peptide-based therapies.

References

1979. Effect of transition metals on recovery from plasma of the growth-modulating tripeptide glycylhistidyllysine. Journal of Chromatography A, 176(2).
DOI: 10.1016/s0021-9673(00)86403-1

2023. Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests. Journal of Cosmetic Dermatology, 22(11).
DOI: 10.1111/jocd.15763

2025. Palmitoyl copper peptide and acetyl tyrosine complex enhances melanin production in both A375 and B16 cell lines. Biochemical and Biophysical Research Communications, 743.
DOI: 10.1016/j.bbrc.2024.151060